Our Team

Name: Macroarc
Telephone: (07) 3138 9047

A/Prof. Hendrik Frisch

Head of the Soft Matter Materials Laboratory, Associate Professor, DECRA Fellow

QUT Contact Details

mailto:h.frisch@qut.edu.au

Brief Curriculum Vitae

since 08/23	Associate Professor
since 2020	ARC DECRA Fellow
09/16 – 12/19	Postdoctoral researcher under supervision of Prof. Barner-Kowollik, Karlsruhe Institute of Technology (KIT), Germany and Queensland University of Technology (QUT), Australia
05/16 – 08/16	Postdoctoral researcher under supervision of Prof. Pol Besenius, JGU Mainz, Germany
11/12 – 04/16	PhD in Organic Chemistry under supervision of Prof. Pol Besenius, WWU Münster and JGU Mainz, Germany
10/10 – 10/12	Master of Science in Chemistry, WWU Münster, Germany
09/11 – 12/11	Research project in the group of Prof. Peter C. Ford, University of California Santa Barbara, USA
10/07 – 10/10	Bachelor of Science in Chemistry, WWU Münster

Research Interests and Opportunities

Advanced Synthetic Tools

Radical Ring-Opening Polymerization
Complex Folding Processes of Polymers into Biomimetic Structures
Solid and Liquid Phase Peptide Synthesis
Peptide-Based Monomer Design
Advanced Light-Induced Reactions, λ-Orthogonal Photoswitches and Photochemistry for Macromolecular Design Radical
Wavelength Resolved Photochemistry and Action Plots
RAFT Agent Design, RAFT Polymer Design
Efficient Bonding/Debonding Polymer Systems, Understanding Dynamic Bonding in Polymer Systems, Photochemical Reversible Bonding Systems

Hybrid Materials

Peptide-Polymer Hybrid Materials
Light Responsive Polymer Materials
Biomimetic Synthetic Molecules, Dynamic Photoresponsive Single Chain Nanoparticles (Towards Synthetic Proteins/Biomimetic Adhesives), Precision Single Chain Nanoparticles for Catalysis
Macromolecular Responsive Nano-Containers

Kinetics and Mechanisms

Intra- and Intermolecular Self-Assembly Processes
Supramolecular Polymerization Kinetics
Controlled Radical Polymerization
Complex Polymer Architecture Formation Processes

Polymer Characterization

High Resolution Mass Spectrometry (ESI-MS, MALDI-TOF) of Synthetic Polymers; Hyphenated Techniques (HPLC/LACCC-ESI, SEC-ESI)
Size Exclusion Chromatography with Multiple Detectors
Small Angle X-Ray Scattering (SAXS)
Circular Dichroism (CD) Spectroscopy

Awards and Prizes

since 2020	ARC Discovery Early Career Researcher Award (DECRA)
since 2019	Merck 350th Anniversary Grant
2017-2019	Fellowship of the German National Academy of Science, Leopoldina
2015	DAAD travel grant for the ‘11th International Conference on Advanced Polymers via Macromolecular Engineering’, Yokohoma, Japan
2014	RSC Chemical Science Poster Prize, ‘Challenges in Nanoscience (ISACS15)’, San Diego, USA
2014	DAAD travel grant for the ‘Challenges in Nanoscience (ISACS15)’, San Diego, USA
2012-2014	PhD Fellowship from the ‘Fonds der Chemischen Industrie’ (FCI)

Presentations

[14]	Remote control of macromolecules with different colors of light: from single chains to materials H. Frisch, Christopher Barner-Kowollik, 37th Australasian Polymer Symposium, Sunshine Coast, Australia. 10-13/11/2019.
[13]	Synthesis of macromolecular architectures with different colors of visible light H. Frisch, Christopher Barner-Kowollik European Polymer Congress EPF 2019, Hersonissos, Greece. 9-14/06/2019.
[12]	Controlling Chemical Reactivity with Different Colors of Light – the Next Frontier in Photochemical Macromolecular Synthesis H. Frisch, Christopher Barner-Kowollik, 12th SPSJ International Polymer Conference, Hiroshima, Japan. 4-7/12/2018. (Invited)
[11]	Creating Macromolecular Architectures with Different Colours of Light H. Frisch, Christopher Barner-Kowollik, Recent Advances in Macromolecular Chemistry, Nagoya, Japan. 3/12/2018. (Invited)
[10]	Visible Light Controlled Macromolecular Architectures H. Frisch, Christopher Barner-Kowollik, 26. Lecture Conference on Photochemistry, Munich, Germany. 10-12/9/2018
[09]	Visible light-gated control of macromolecular architectures H. Frisch, Christopher Barner-Kowollik, MACRO18 World Polymer Congress, Cairns, Australia. 1-5/7/2018
[08]	Reprogramming Chemical Bonds with Different Colours of Light H. Frisch, Christopher Barner-Kowollik, International Symposium of Photopolymer Science, Wuxi, China. 23-25/4/2018. (Invited)
[07]	pH-Control of Supramolecular Polymerizations in Water H. Frisch, P. Besenius. IUPAC 11th International Conference on Advanced Polymers via Macromolecular Engineering (APME 2015), Yokohama, Japan. 18-22/10/2015.
[06]	Controlling Supramolecular Polymerizations in Water H. Frisch, P. Besenius. 5th Training School on Supramolecular Chemistry in Water, Padova, Italy. 11-14/11/2014.
[05]	pH Responsive Supramolecular Polymerizations H. Frisch, P. Besenius. POLY Symposium “Responsive Nanostructures and Nanocomposites”, 247th ACS National Meeting, Dallas, US. 16-20/3/2014.
[04]	pH-Gesteuerte supramolekulare Polymerisationen in Wasser H. Frisch, P. Besenius. Regionales Stipendiatentreffen des Fonds der Chemischen Industrie (FCI), Münster, Germany. 12/12/2013.
[03]	pH Controlled Supramolecular Polymerization H. Frisch, P. Besenius. Ghent-Münster Mini-Symposium in Supramolecular and Polymer Chemistry, CeNTech, Münster, Germany. 10/10/2013.
[02]	Controlling Supramolecular Copolymerisation via pH H. Frisch, P. Besenius. IUPAC 10th International Conference on Advanced Polymers via Macromolecular Engineering (APME), Durham, UK. 18-22/8/2013.
[01]	Responsive Supramolecular Copolymers H. Frisch, P. Besenius. 2nd German Symposium in Supramolecular Chemistry, Münster, Germany. 14-15/2/2013.

Publications

2024

[764]	*How Molecular Architecture Defines Quantum Yields* Pashley-Johnson, F.; Munaweera, R.; Houssain, S. I.; Gauci, S.; Delafresnaye, L.; Frisch, H.; O’Mara, M. L.; Du Prez, F. E.; Barner-Kowollik, C. Nat. Commun. 2024, 15, 6033
[758]	*Visible Light Photoflow Synthesis of a Cu(II) Single-Chain Polymer Nanoparticle Catalyst* Gillhuber, S.; Holloway, J. O.; Mundsinger, K.; Kammerer, J. A.; Frisch, H.; Barner-Kowollik, C.; Roesky, P. W. Chem. Sci. 2024, 15, 15280-15290.
[757]	*Förster resonance energy transfer within single chain nanoparticles* Maag, P. H.; Feist, F.; Frisch, H.; Roesky, P. W.; Barner-Kowollik, C. Chem. Sci. 2024, 15, 5218-5224.
[756]	*Photochemical Action Plots Reveal Red-shifted Wavelength-dependent Photoproduct Distributions* Carroll, J. A.; Pashley-Johnson, F.; Frisch, H.; Barner-Kowollik, C. Chem. Eur. J. 2024, 30, e202304174.

2023

[745]	*Simultaneously Recorded Photochemical Action Plots Reveal Orthogonal Reactivity* Irshadeen, I. M.; Truong, V. X.; Frisch, H.; Barner-Kowollik, C. Chem. Commun. 2023, 59, 11959-11962.
[738]	*Visible-Light-Induced Control over Reversible Single-Chain Nanoparticle Folding* Maag, P. H.; Feist, F.; Truong, V. X.; Frisch, H.; Roesky, P. W.; Barner-Kowollik, C. Angew. Chem. Int. Ed. 2023, 62, e202309259.
[736]	*Ferrocene-driven single-chain polymer Compaction* Gillhuber, S.; Holloway, J. O.; Frisch, H.; Feist, F.; Weigend, F.; Barner-Kowollik, C.; Roesky P. W. Chem. Commun. 2023, 59, 4672-4675.
[04]	*Programming Photodegradability into Vinylic Polymers via Radical Ring-Opening Polymerization* Do, P. T.; Poad, B. L. J.; Frisch, H. Angew. Chem. Int. Ed. 2023, 62, e202213511.
[734]	*Two Functions from a Single Photoresist: Tuning Microstructure Degradability from Light-Stabilized Dynamic Materials* Gauci, S. C.; Ehrmann, K.; Gernhardt, M.; Tuten, B.; Blasco, E.; Frisch, H.; Jayalatharachchi, V.; Blinco, J. P.; Houck, H. A.; Barner-Kowollik, C. Adv. Mater. 2023, 35, 2300151.
[712]	*3D Printed Microstructures Erasable by Darkness* Gauci, S. C.; Gernhardt, M.; Frisch, H.; Houck, H. A.; Blinco, J. P.; Blasco, E.; Tuten, B. T.; Barner-Kowollik, C. Adv. Funct. Mater. 2023, 33, 2206303.

2022

[03]	*Peptide based folding and function of single polymer chains* Kalmer, H.; Sbordone, F.; Frisch, H. Polym. Chem. 2022, 13, 5458-5462.
[02]	*Trends in Polymer Degradation Across All Scales* Veskova, J.; Sbordone, F.; Frisch, H. Macromol. Chem. Phys. 2022, 223, 2100472.
[725]	*Red Light Induced Folding of Single Polymer Chains* Irshadeen, I. M.; Truong, V. X.; Frisch, H.; Barner-Kowollik, C. Chem Commun. 2022, 58, 12975-12978.
[723]	*Fluorescent and Catalytically Active Single Chain Nanoparticles* Maag, P. H.; Feist, F.; Frisch, H.; Roesky, P. W.; Barner-Kowollik, C. Macromolecules 2022, 55, 9918-9924.
[708]	*Green Light Enabled Staudinger-Bertozzi Ligation* Kalayci, K.; Frisch, H.; Barner-Kowollik, C.; Truong, V. X. Chem Commun. 2022, 58, 6397-6400.
[707]	*Photostationary State in Dynamic Covalent Networks* Chambers, L. C.; Barner-Kowollik, C.; Barner, L.; Michalek, L.; Frisch, H. ACS Macro Lett. 2022, 11, 532-536.
[705]	*Orange-Light-Induced Photochemistry Gated by pH and Confined Environments* Kodura, D.; Rodrigues, L. L.; Walden, S. L.; Goldmann, A. S.; Frisch, F.; Barner-Kowollik, C. J. Am. Chem. Soc. 2022, 144, 6343-6348.
[687]	*Light-Gated Control of Conformational Changes in Polymer Brushes* Bialas, S.; Krappitz, T.; Walden, S. L.; Kalayci, K.; Kodura, D.; Frisch, H.; MacLeod, J. M.; Nelson, A.; Michalek, L.; Barner-Kowollik, C. Adv. Mater. Technol. (Special Issue), 2022, 7, 2100347.

2021

[697]	*Action Plots in Action: In-Depth Insights into Photochemical Reactivity* Irshadeen, I. M.; Walden, S. L.; Wegener, M.; Truong, V. X.; Frisch, H.; Blinco, J. P.; Barner-Kowollik, C. J. Am. Chem. Soc. 2021, 143, 21113-21126.
[689]	*Green Light LED Activated Ligation of a Scalable, Versatile Chalcone Chromophore* Irshadeen, I. M.; de Bruycker, K.; Micallef, A. S.; Walden, S. L.; Frisch, H.; Barner-Kowollik, C. Polym. Chem. 2021, 12, 4903-4909.
[685]	*Wavelength-Selective Softening of Hydrogel Networks* Pelloth, J. L.; Tran, P. A.; Walther, A.; Goldmann, A. S.; Frisch, H.; Truong, V. X.; Barner-Kowollik, C. Adv. Mater. 2021, 33, 2102184.
[674]	*Modular Functionalization and Hydrogel Formation via Red-shifted and Self-reporting [2+2] Cycloadditions* Ludwanowski, S.; Hoenders, D.; Kalayci, K.; Frisch, H.; Barner-Kowollik, C.; Walther, A. Chem. Commun. 2021, 57, 805-808.
[648]	*Computational Prediction of the Molecular Configuration of Three-Dimensional Network Polymers* De Keer, L.; Kilic, K. I.; Van Steenberge, P. H. M.; Daelemans, L.; Kodura, D.; Frisch, H.; De Clerck, K.; Reyniers, M. F.; Barner-Kowollik, C.; Dauskardt, R. H.; D’hooge, D. R. Nat. Mater. 2021, 20, 1422-1430. (see journal cover)
[636]	*Light-Fueled Dynamic Covalent Crosslinking of Single Polymer Chains in Non-Equilibrium States* Kodura, D.; Houck, H. A.; Bloesser, F. R.; Goldmann, A. S.; Du Prez, F. E.; Frisch, H.; Barner-Kowollik, C. Chem. Sci. 2021, 12, 1302-1310.

2020

[01]	*Photocycloreversions within single polymer chains* Liu, M.; Wenzel, W.; Frisch, H. Polym. Chem. 2020, 11, 6616-6623.
[656]	*A Holistic Approach for Anthracene Photochemistry Kinetics* Kislyak, A.; Kodura. D.; Frisch, H.; Feist, F.; Van Steenberge, P. H. M.; Barner-Kowollik, C.; D’hooge, D. R Chem. Eng. J. 2020, 402, 126259.
[653]	*Green Light Triggered [2+2] Cycloaddition of Halochromic Styrylquinoxaline – Controlling Photoreactivity by pH* Kalayci, K.; Frisch, H.; Truong, V. X.; Barner-Kowollik, C. Nat. Commun. 2020, 11, 4193.
[651]	*Photocycloadditions in Disparate Chemical Environments* Marschner D. E; Kamm, P. W.; Frisch, H.; Unterreiner, A.-N.; Barner-Kowollik, C. Chem. Commun. 2020, 56, 14043-14046.
[649]	*Multi-material 3D Microstructures with Photochemically Adaptive Mechanical Properties* Gernhardt, M.; Frisch, H.; Welle, A.; Jones, R.; Wegener, M.; Blasco, E.; Barner-Kowollik, C. J. Mater. Chem C 2020, 8, 10993-11000.
[644]	*2D Fabrication of Tuneable Responsive Interpenetrating Polymer Networks from a Single Photoresist* Michalek, L.; Bialas, S.; Walden, S.; Bloesser, F. R.; Frisch, H.; Barner-Kowollik, C. Adv. Funct. Mater. 2020, 30, 2005328.
[630]	*Tacticity Dependence of Single Chain Polymer Folding* Danilov, D.; Sedghamiz, E.; Fliegl, H.; Frisch, H.; Barner-Kowollik, C.; Wenzel, W. Polym. Chem. 2020, 11, 3439-3445.
[627]	*Macromolecular Superstructures: A Future Beyond Single Chain Nanoparticles* Frisch, H.; Tuten, B. T.; Barner-Kowollik, C. Isr. J. Chem. 2020, 60, 86-99. (invited contribution to Rosarium Philosophorum)
[624]	*Wavelength-Dependent Stiffening of Hydrogel Matrices via Redshifted [2+2] Photocycloadditions* Kalayci, K.; Frisch, H.; Barner-Kowollik, C., Truong, V. X. Adv. Funct. Mater. 2020, 30, 1908171.
[622]	*Wavelength-Gated Photoreversible Polymerization and Topology Control* Frisch, H.; Mundsinger, K.; Poad, B. L. J.; Blanksby, S. J.; Barner-Kowollik, C. Chem. Sci. 2020, 11, 2834-2842.
[614]	*Wavelength-Selective Folding of Single Polymer Chains with Different Colors of Visible Light* Frisch, H.; Kodura, D.; Bloesser, F. R.; Michalek, L.; Barner-Kowollik, C. Macromol. Rapid Commun. 2020, 41, 1900414. (Special Issue dedicated to 100 Years of Macromolecular Chemistry) (see journal cover)
[04]	*Revealing the Wavelength Dependence of Photochemical Reactions: Cutting-Edge Research in the Teaching Lab* Walden, S.; Frisch, H.; Unterreiner, B.; Unterreiner, A.-N.; Barner-Kowollik, C. J. Chem. Educ. 2020, 97, 543-548.
[610]	*Time-Dependent Differential and Integral Quantum Yields for Wavelength-Dependent [4+4] Photocycloadditions* Kislyak, A.; Frisch, H.; Gernhardt, M.; Van Steenberge, P. H. M.; D’hooge, D. R.; Barner-Kowollik, C. Chem. Eur. J. 2020, 26, 478-484.

2019

[564]	*Synthesis of Single-Ring Nanoparticles Mimicking Natural Cyclotides by a Stepwise Folding-Activation-Collapse Process* Rubio-Cervilla, J.; Frisch, H.; Barner-Kowollik, C.; Pomposo, J. Macromol. Rapid Commun. 2019, 40, 1800491. (special issue 40 years MRC)
[569]	*Contemporary Photoligation Chemistry: The Visible Light Challenge* Offenloch, J. T.; Gernhardt, M.; Blinco, J. P.; Frisch, H.; Mutlu, H.; Barner-Kowollik, C. Chem. Eur. J. 2019, 25, 3700-3709.
[583]	*Controlling Chain Coupling and Single-Chain Ligation by Two Colours of Visible Light* Frisch, H.; Bloesser, F. R.; Barner-Kowollik, C. Angew. Chem. Int. Ed. 2019, 58, 3604-3609.
[587]	*Access to Disparate Soft Matter Materials by Curing with two Colors of Light* Bialas, S.; Michalek, L.; Marschner, D. E.; Krappitz, T.; Wegener, M.; Blinco, J. P.; Blasco, E.; Frisch, H.; Barner-Kowollik, C. Adv. Mater. 2019, 31, 1807288.
[597]	*Tailoring the Mechanical Properties of 3D Microstructures Using Visible Light Post-Manufacturing* Gernhardt, M.; Blasco, E.; Hippler, M., Blinco, J. P.; Bastmeyer, M.; Wegener, M.; Frisch, H.; Barner-Kowollik, C. Adv. Mater. 2019, 31, 1901269.
[616]	*Hybrid Photo-induced Copolymerization of Ring-Strained and Vinyl Monomers Utilizing Metal-Free Ring-Opening Metathesis Polymerization Conditions* Krappitz, T.; Jovic, K.; Feist, F.; Frisch, H.; Rigoglioso, V. P.; Blinco, J. P.; Boydston, A. J.; Barner-Kowollik, C. J. Am. Chem. Soc. 2019, 141, 16605-16609.

2018

[568]	*Making and Breaking Chemical Bonds by Chemiluminescence* Kockler, K. B.; Frisch, H.; Barner-Kowollik, C. Macromol. Rapid Commun. 2018, 39, 1800516. (see journal cover)
[558]	*Photochemistry in Confined Environments for Single-Chain Nanoparticle Design* Frisch, H:, Menzel, J. P.; Bloesser, F. R.; Marschner, D.; Mundsinger, K.; Barner-Kowollik, C. J. Am. Chem Soc. 2018, 140, 9551-9557. (see journal cover)
[537]	*Visible Light [2+2] Cycloadditions for Reversible Polymer Ligation* Marschner, D. E.; Frisch, H.; Offenloch, J. T.; Tuten, B. T.; Becer, R.; Walther, A.; Goldmann, A. S.; Tzvetkova, P.; Barner-Kowollik, C. Macromolecules 2018, 51, 3802-3807.
[527]	*Wavelength-Gated Dynamic Covalent Chemistry* Frisch, H.; Marschner, D.; Goldmann, A. S.; Barner-Kowollik, C. Angew. Chem. Int. Ed. 2018, 57, 2036-2045.

2017

[39]	*Tuning the pH-Switch of Supramolecular Polymer Carriers for siRNA to Physiologically Relevant pH* Ahlers, P. ; Frisch, H.; Holm, R.; Spitzer, D.; Barz, M.; Besenius, P. Macromol. Biosci. 2017, 17, 1700111.
[514]	*Characterizing Single Chain Nanoparticles (SCNPs): A Critical Survey* Blasco, E.; Tuten, B. T.; Frisch, H.; Lederer, A.; Barner-Kowolik, C. Polym. Chem. 2017, 8, 5845-5851.

2016

[41]	*Probing the Self-Assembly and Stability of Oligohistidine based Rod-like Micelles by Aggregation Induced Luminescence* Frisch, H.; Spitzer, D.; Haase, M.; Basché, T.; Voskuhl, J.; Besenius, P. Org. Biomol. Chem. 2016, 14, 5574-5579.
[40]	*Kinetically Controlled Sequential Growth of Surface-Grafted Chiral Supramolecular Copolymers* Frisch, H.; Fritz, E.-C.; Stricker, F.; Schmüser, L.; Spitzer, D.; Weidner, T.; Ravoo, B. J.; Besenius, P. Angew. Chem. Int. Ed. 2016, 55, 7242-7246.

2015

[44]	*pH-Switchable Self-Assembled Materials* Frisch, H.; Besenius, P. Macromol. Rapid Commun. 2015, 36, 346-363.
[43]	*pH-Regulated Selectivity in Supramolecular Polymerizations: Switching Between Co- and Homopolymers* Frisch, H.; Nie, Y.; Raunser, S.; Besenius, P. Chem. Eur. J. 2015, 21, 3304-3309.
[42]	*Tuneable pH-Regulated Supramolecular Copolymerisation by Mixing Mismatched Dendritic Peptide Comonomers* Ahlers, P.; Frisch, H.; Besenius, P. Polym. Chem. 2015, 6, 7245-7250.

2014

[46]	*Zwitterionic Phosphirenium Borates Derived from Bis(alkynyl)mesityl Phosphanes and Tris(pentafluorophenyl)borane* Möbus, J.; Malessa, K.; Frisch, H.; Daniliuc, C. G.; Fröhlich, R.; Kehr, G.; Erker, G. Heteroat. Chem. 2014, 25, 396-401.
[45]	*The Synthesis of Dendritic EDOT-Peptide Conjugates and Their Multistimuli-Responsive Self-Assembly Into Supramolecular Nanorods and Fibres in Water* Ahlers, P.; Frisch, H.; Spitzer, D.; Vobecka, Z.; Vilela, F.; Besenius, P.; Chem. Asian J. 2014, 9, 2052-2057.

2013

[48]	*A Soft Supramolecular Carrier with Enhanced Singlet Oxygen Photosensitizing Properties* Voskuhl, J.; Kauscher, U.; Gruener, M.; Frisch, H.; Wibbeling, B.; Strassert, C. A.; Ravoo, B. J. Soft Matter 2013, 9, 2453-2457.
[47]	*pH-Switchable Ampholytic Supramolecular Copolymers* Frisch, H.; Unsleber, J. P.; Lüdeker, D.; Peterlechner, M.; Brunklaus, G.; Waller, M.; Besenius, P. Angew. Chem. Int. Ed. 2013, 52, 10097-10101.

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